Tailoring Endometrial Cancer Treatment Based on Molecular Pathology: Current Status and Possible Impacts on Systemic and Local Treatment.

Int J Mol Sci · 2024 · PMC11276773 · PMID 39062983

Europe PMC DOI

hedged sentences

0.0240

closest p · 0.5× alpha

0.0240

boldest claim

The sentences

did not reach statistical significancep = 0.024actually significant

The study did not reach statistical significance in the intention-to-treat population, with a median PFS of 5.7 months for selinexor versus 3.8 months for the control arm (HR 0.70; p = 0.024).

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showed a trendno p-value reported

chemotherapy alone showed a trend in reduced risk of death by 21% (HR = 0.79, 95% CI = 0.602–1.044) and a clinically meaningful improvement of 7 months in median overall survival (34.0 months vs. 27.0 months).

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