Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.

Behaviorally, SERT −/− rats showed a nonsignificant trend for more accurate responses to the CS−.

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While genotype and training × genotype had an almost significant effect on the MD in CS+ trials with SERT −/− rats showing slower speed of response in the initial trial bins ( Fig. 1K , Table S1 ), the influence of training on MD was different in both genotypes for CS− trials with incorrect responses and SERT +/+ rats eventually showed a slower speed of response in the last trial bin (SERT +/+ rats: 1,189 ± 302 ms, SERT −/− rats: 859 ± 294 ms).

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In contrast, the accuracy and the number of corrections for CS− trials were not influenced by training but both showed a trend for a genotype effect that did not reach statistical significance ( Fig. 2C and E , Table S2 ).

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In contrast, the accuracy and the number of corrections for CS− trials were not influenced by training but both showed a trend for a genotype effect that did not reach statistical significance ( Fig. 2C and E , Table S2 ).

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