Dissecting Acute Drug-Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver-On-A-Chip Model.

Comparably, metabolism‐related gene expression changes did not reach statistical significance in the LoC except for an increased Cd36 expression, although Pparg , Shbg , and Xbp1 levels were increased in singular hepatocyte culture (Figure 6F ; Figure S14D,E , Supporting Information).

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The quantification only showed a trend to a reduced lipid accumulation, when lanifibranor was added to the culture (Figure 3F ).

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