Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice.

Although it did not reach statistical significance, relatively higher p-eIF2α immunostaining in β cells was observed in 6- and 8-week-old mice compared with 10- and 12-week-old mice ( Supplemental Figure 1 , A and B; supplemental material available online with this article; https://doi.org/10.1172/JCI176136DS1 ); further studies were therefore focused on NOD mice before 10 weeks of age.

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Immunostaining of pancreata showed a trend toward an increased number of proliferating cell nuclear anthigen–positive (PCNA-positive) β cells upon HC-5770 treatment ( Supplemental Figure 3 , G and H) and no changes in β cell death by TUNEL assay ( Supplemental Figure 3 , G and I).

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