Extracellular NAD⁺ response to post-hepatectomy liver failure: bridging preclinical and clinical findings.

The mixed-effects model analysis indicates highly significant effects of time, treatment groups, and their interaction on hepatocyte viability ( p < 0.0001 for all).

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Although there was a slight trend in expression for both enzymes as the fibrosis stage increased, the observed changes did not reach statistical significance (Fig. 4 e, f ).

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Post-operative eNAD + levels decreased significantly ( p < 0.05), but in advanced stages of liver fibrosis or cirrhosis, this decline not only diminished but actually showed a trend towards an increase.

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