Risk willingness in multiple system atrophy and Parkinson's disease understanding patient preferences.

Despite no significant association between attitudes or intentions towards clinical trials and risk willingness, a clear trend indicated that participants with higher intentions to participate were more inclined to accept greater therapy-associated risks (Supplementary Figs. 9 and 10 ).

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While the results did not reach statistical significance, our analysis revealed a clear trend where MSA-C patients exhibited a lower willingness to accept specific therapy-associated risks compared to MSA-P patients (Supplementary Fig. 11 ).

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