a negative trendp=0.036
A lower frequency of more immature subpopulations expressing PD1+ was also observed within the effector response (EM Th0-1 and TEMRA pE1), as well as a negative trend in CM cells (p=0.036, q=0.159).
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Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era.
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0.0360
0.0480
The sentences
a positive trendp=0.037
LLV showed higher activation of N and TEMRA pE1 cells, as well as a positive trend in EM Th1 cells (p=0.037, q=0.590).
an increasing trendp=0.048
Similar activation levels were observed throughout CD8+ T-cell development, except for an increasing trend in activated (HLADR+) CM (p=0.048, q=0.993) and TEMRA E (p=0.015, q=0.736) subpopulations in LLV.
In addition, LLV also showed a trend toward increased activation of CD8+ TEMRA E T-cells and increased expression of exhaustion markers, primarily within the CD8+ EM and TEMRA T response.