A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age.

We found a highly significant correlation between chronological age and epigenetic age for both baseline (V1) and week 12 (V2) calculated using the Hannum (V1: p < 0.0001, R = 0.74; V2: p < 0.0001, R = 0.77; Fig. 2 A) and Horvath (V1: p < 0.0001, R = 0.69; V2: p < 0.0001, R = 0.70; Fig. 2 B) clocks.

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There was a strong trend to a decrease in epigenetic age acceleration in female participants with the novel InflammAge clock ( p = 0.05, Suppl.

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Participants with the lowest quartile mean SF36 score showed a trend towards a positive effect of the supplement (V1: 626, V2: 663, p = 0.08).

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