Sleep spindles are reduced in children with Down syndrome and sleep-disordered breathing.

31 In that study, we had hypothesized that spindle numbers would be related to SDB severity; however, we found that spindle numbers were much more variable in the children with SDB and although there was a tendency for reduced spindles in the PS and MS OSA groups, this failed to reach statistical significance.

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For Fast spindles, 27% of children with DS had none recorded on frontal electrodes compared to 14% of TD children and 30% compared to 16% on centroparietal electrodes; however, these differences did not reach statistical significance.

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