Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes.

Similarly, early stage P2/3 PanNETs of G1/2 showed a trend for shorter RFS time than P1/4 ( Figure S1 F).

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The external transcriptome datasets showed most MMPs were highly expressed in hypoxia-high group, however, mRNA MMP11 did not reach statistical significance ( Figure S2 B).

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