DNA Methylation of <i>PXDN</i> Is Associated with Early-Life Adversity in Adult Mental Disorders.

Interestingly, comparisons between BPD patients with and without ELA identified changes in cg10888111 methylation within the gene PXDN that were, although only nominally significant in the EWAS performed in the discovery cohort, significant when validated with a targeted EpiTYPER assay in the same cohort [ 18 ].

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Sexual abuse—known to associate strongly with the development of BPD [ 39 ]—showed a trend towards a weak positive correlation with cg10888111 methylation levels (Spearman’s rho = 0.11, p .adj. = 0.051; Figure S8C ). 4.4.

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