Unique miRNA Expression Profile in MSI- and EMAST-Unstable Sporadic Colon Cancer.

The results showed a trend, but did not reach statistical significance, in the increased expression of let-7i-5p in smaller tumors, which goes in line with the consideration that miRNAs from the let-7 family are tumor suppressors [ 56 ] and have been shown to be significantly downregulated in ovarian and bladder advanced tumors [ 57 , 58 ].

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We also observed an increased expression of let-7i-5p in smaller tumors (less than 5 cm across) ( p = 0.0502, Figure 4 C); however, this result did not reach statistical significance. 4.

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