Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation.

An almost significant increase in the colon weight/length ratio in let-7b-treated mice was found ( Figure 6(b) ).

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After miR-21, the mRNA expression of the most predominant mucin in the colon Mucin 2 ( Muc2 ) exhibited a reduction, although this did not reach statistical significance.

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Whereas, let-7b showed a trend to increase in the expression of Muc1 , which primary function is cell protection; and significantly decreased Muc5b , mainly found in goblet cells ( Figure 5(a) ).

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