Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice.

The PKG2 R242Q -expressing osteoblasts showed a trend toward higher BrdU incorporation ( P = 0.051) and significantly reduced cleaved caspase-3 staining compared with WT osteoblasts under basal conditions ( Figure 2, A and B ).

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The Prkg2 R242Q transgenic mice had higher femoral and tibial cortical bone volumes compared with their WT littermates, as previously described ( 15 ), but there was no difference in vertebral cortical volumes between the genotypes ( Figure 4, B–D, F, and G ; the trend toward higher tibial Ct.Th did not reach statistical significance).

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