Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary disease.

Hypoxia-Conditioned Extracellular Vesicles Improve Myocardial Perfusion Myocardial perfusion analysis showed a trend toward increased myocardial perfusion at rest and a significant increase in ischemic myocardial perfusion while pacing the heart at 150 bpm in the HEV group when compared with the CON group ( P = .09, P < .001, Figure 2 , A , Table E2 ).

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In addition to marker analysis, our blood flow assays showed that the ischemic myocardium of the HEV group exhibited a significant increase in myocardial perfusion during rapid ventricular pacing, as well as a strong trend toward increased myocardial perfusion at rest.

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