Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids.

Acta Neuropathol Commun · 2024 · PMC11409520 · PMID 39289761

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did not reach statistical significanceno p-value reported

6 j; Chi-square test, Χ 2 (1) = 0.7212, p = 0.3958), but this effect did not reach statistical significance.

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showed a trendno p-value reported

However, further analysis showed that organoids of (1) C9-carrier-3 and -4 were significantly larger ( p adj < 0.0001 and 0.0030) than HC, (2) C9-carrier-2 showed a trend to be larger ( p adj = 0.0511), and (3) C9-carrier-1 were not different from HC ( p adj = 0.5376).

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