Predictors of improvement in disease activity in childhood and adolescent Crohn's disease: an analysis of age, localization, initial severity and drug therapy - data from the Saxon Registry for Inflammatory Bowel Disease in Children in Germany (2000-2014).

Furthermore, an unfavorable trend has been observed in terms of the age at diagnosis, showing a shift toward early childhood years [ 3 – 5 ].

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However, these differences did not reach statistical significance in the log-rank test (Table 7 , Fig. 6 in Appendix A).

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