Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts.

On the other hand, for model 3, the MoRSAE approached significance in association with PTSD in the NCPTSD-TRACTS cohort (beta = -0.1707, p = 0.05) and had significant difference in risk scores between cases and controls ( p = 0.018) (Figure S7); however, the direction of effect was opposite to that observed in the discovery cohort.

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Assessment of biological significance among Important CpGs Gene ontology (GO) analysis on the set of 3728 CpGs from models 1 and 2 revealed 403 nominally significant GO terms; among the 4150 important CpGs from Model 3, 382 nominally significant GO terms were identified.

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