Genetic Modifiers of ALS: The Impact of Chromogranin B P413L in a Bulgarian ALS Cohort.

At the genotype level, C/T heterozygotes showed a trend toward earlier onset compared to C/C homozygotes, while T/T homozygotes had a later mean onset.

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In contrast, in the Bulgarian control groups, we only observed an increase in the homozygous T/T genotype, although these differences did not reach statistical significance at the α < 0.05 level.

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