Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics.

The heatmap showed that eight of the overlapping and differentially changed metabolites have a marked trend of “high–low–high” or “low–high–low”, such as 11-dehydrocorticosterone, 9,10-EpOME, 12,13-EpOME, rhapontigenin, Glu-Thr, and phytosphingosine, which were deemed as key serum metabolites in SW033291-ameliorated T2DM.

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Cluster heatmap analysis showed that 14 overlapping and differentially expressed genes have a significant trend of “high–low–high” or “low–high–low”, such as steroid 21-hydroxylase ( Cyp21a1 ), ciliogenesis and planar polarity effector 1 ( Cplane1 ), glutathione S-transferase Mu 3 ( Gstm3 ), glutathione S-transferase Mu 1 ( Gstm1 ), pyrethroid hydrolase Ces2a ( Ces2a ), and cytochrome P450 3A11 ( Cyp3a11 ) ( Figure 4 A).

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