Acute estradiol and progesterone therapy in hospitalized adults to reduce COVID-19 severity: a randomized control trial.

Compared to placebo-eq patients, E2P4 patients showed significantly decreased IL-6, showed a trend toward decrease in IL-33, IL-10, and IL-17 C, and had diminished IL-7 increase in both the combined and men-only groups (Fig. 1 A–C).

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placebo arm but did not reach statistical significance (Table 2 ).

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