Pilot Study of IL-1 Antagonist Anakinra for Treatment of Endometriosis.

Int J Womens Health · 2024 · PMC11444056 · PMID 39355382

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.0790

boldest claim

The sentences

showed a trendp = 0.04actually significant

All domains of the EHP-30 showed a trend towards improvement, with significant improvements in powerlessness (54.5 vs 63.3, p = 0.04) and self-image (58.1 vs 66.7, p = 0.03) on the study drug compared to placebo.

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a trend towards significancep = 0.0790so close (0.05 < p ≤ 0.1)

When all participants are included, not only the 6 who completed all blood draws for all cycles, there is still a trend towards significance (p = 0.0790, Figure 3B ).

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did not reach statistical significanceno p-value reported

However, when data from all subjects with any blood draws were analyzed, BDNF levels trended down but did not reach statistical significance with anakinra treatment.

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