Difference between hand and forearm transepidermal water loss and skin pH as an improved method to biomonitor occupational hand eczema: our findings in healthcare workers.

Considering that we found no significant association between hand TEWL and increased glove use but did find a significant trend of worsening of relative parameters ΔTEWL, ΔTEWL%, ΔpH, and ΔpH%, our study has confirmed the hypothesised utility of using the forearm as a personal baseline when investigating skin health on hands exposed to occupational hazards.

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There was a clear trend of increasing median ΔTEWL%, starting from physicians with non-surgical specialisation (56 %) to medical surgeons (65 %), dentists (104 %), and dental surgeons (108 %), with the latter two groups showing particularly worrisome signs of work-related skin barrier impairment, since they had double the TEWL on hands than on forearms.

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