Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity.

Immunization with AA05 WT trended to elicit higher V1V2 and V3 Abs compared to AA05-02 however it did not reach statistical significance ( Figure 8E middle panel).

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In contrast, Group 4 (AC02-05) showed a trend of lower Ab reactivity than Group 3 (AC02 WT).

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