Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.

Transl Neurodegener · 2024 · PMC11460072 · PMID 39380076

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hedged sentences

0.0980

closest p · 2.0× alpha

0.0980

boldest claim

The sentences

showed a trendP = 0.098so close (0.05 < p ≤ 0.1)

YAC128 mice treated with 50 μg HTT ASO showed a trend toward increased plasma NfL compared to PBS at each time point over the 3-month interval, which was highest at 1-month post-treatment ( P = 0.098).

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a strong trendno p-value reported

A strong trend towards a significant treatment effect on plasma NfL concentrations was observed over the 6-month interval in response to 50 μg HTT ASO treatment initiated at 8 months of age (Fig.

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