Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression.

AML cells from the BM of ANXA5-deficient mice showed a trend toward increased ROS ( supplemental Figure 15 F) and a significant increase of DNA damage ( Figure 4 E).

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Consistently, ANXA5 KO MSCs showed a strong trend toward increased formation of fibroblast colonies (colony-forming units fibroblast; supplemental Figure 9 A) but decreased osteogenic and unchanged adipocytic differentiation ( supplemental Figure 9 B-C).

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