Pre- and postsynaptic signatures in the prelimbic cortex associated with "alcohol use disorder" in the rat.

Additionally, there was a significant effect of time across all groups (df=68, 0crit: t = 3.533 p = 0.001, 1crit: t = 2.038 p = 0.045, 2crit: t = 2.625 p = 0.011) except for the 3crit rats that nevertheless approached significance (t = 1.904 p = 0.061) (total active lever presses presented in Fig.

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In addition, 3crit rats displayed altered I/V relationships and showed a strong trend towards increased AP firing and reduced rheobase, indicating that the ability of PL pyramidal neurons to generate an AP was enhanced in rats displaying AUD-like behavior.

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