Physiologically Achievable Concentration of 2-Deoxy-D-Glucose Stimulates IFN-γ Secretion in Activated T Cells In Vitro.

While 0.6 mM 2DG did not substantially reduce IL-2 secretion, there was a clear trend towards lower IL-2 levels with the 4.8 mM 2DG treatment ( Figure 3 E, ns).

also in 6,582 other papers

We observed a slight trend towards a lower percentage of T-bet+ cells in both CD4+ ( Figure 6 A, ns) and CD8+ ( Figure 6 B) 2DG-treated T cells.

also in 1,214 other papers

PD-1 expression level was reduced by both 2DG concentrations to a similar degree (60% of control) in CD4+ cells, while in CD8+ cells, only a weak trend of decreased PD-1 (ns) was observed ( Figure 1 G,H).

also in 323 other papers

However, we should note that 0.6 mM 2DG consistently increased CD69 levels regardless of treatment timing and even showed a trend towards higher IL-2 levels when administered at the beginning of activation.

also in 16,965 other papers