Prospective Variation of Cytokine Trends during COVID-19: A Progressive Approach from Disease Onset until Outcome.

In contrast, survival patients showed a trend of increasing IFN-γ levels throughout the infection.

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Notably, there is a clear trend of increasing IL-6 levels in the death group, while in the survival group, the trend decreased.

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Our prospective analysis of IL-6 showed an increasing trend in marker levels in the death group.

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Specifically, IFN-γ levels rose progressively in the survival group over time, while in the death group, IFN-γ levels were initially elevated but demonstrated a decreasing trend as the infection progressed ( Figure 3 A).

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