Although the difference in protein levels between brain donors with SCZ and NPs did not reach statistical significance ( P > .05), these findings indicate that inflammasome proteins are present in the brains of individuals with and without SCZ and may require description at the cellular resolution using IHC techniques to identify changes in expression within individual cell populations ( Figure S1 ).
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Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia.
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Results from Western-blot analyses of brains from donors with SCZ and NPs showed a trend of higher averages of inflammasome protein levels in the brains from donors with SCZ when compared to unaffected NPs, although these differences were not statistically significant.