Growth hormone-releasing hormone deficiency confers extended lifespan and metabolic resilience during high-fat feeding in mid and late life.

A similar pattern was observed in GHRH‐KO males, with GHRH‐KO + HFD males displaying a median lifespan of 2.33 years and GHRH‐KO + CD males displaying a median lifespan of 2.47 years, which trended toward but did not reach statistical significance ( p = 0.0622; log‐rank test, Figure 1c ).

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GHRH‐KO females fed HFD displayed a median lifespan of 2.35 years which was shorter than the 3.47‐year median lifespan of GHRH‐KO females fed CD but failed to reach statistical significance when analyzed by a log‐rank test (Figure 1b ).

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