Although MR Egger results did not reach statistical significance, the direction of effect (i.e. direction of the beta) was consistent, reinforcing the observed results.
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The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.
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Finally, through sex-specific MR, we observed a potential near-significant causal effect of iron levels on Parkinson’s disease among females in our primary analysis using the inverse variance weighted approach (OR [95% CI] = 0.79 [0.64–0.98], p = 0.03).