Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo.

First of all, those R1 region TFCRs, which we call proximal TFCRs (p-TFCRs), also showed a strong correlation between TC and gene expression level at early embryonic developmental stages, and at the same time, showed a clear trend of increasing correlation at 8Cell and later stages ( Fig. 4 A, Fig.

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Next, we explored the associated genes of TFCRs in the R1-R4 region and found that the highly expressed (H group, FPKM>1) genes also showed a trend of increasing in the R1 region and decreasing in the R4 region with developmental progression ( Fig.

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