PI3K Mutation Profiles on Exons 9 (E545K and E542K) and 20 (H1047R) in Mexican Patients With HER-2 Overexpressed Breast Cancer and Its Relevance on Clinical-Pathological and Survival Biological Effects.

Int J Breast Cancer · 2024 · PMC11496583 · PMID 39444377

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

a near-significant trendp = 0.053so close (0.05 < p ≤ 0.1)

Nonetheless, a near-significant trend was observed in the overall response rate (68.6% vs. 33%; p = 0.053) and a significant decrease in Ki67 levels (75% vs. 26.7%; p = 0.021) in the subgroup of patients with HR+/HER-2+ tumors.

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did not reach statistical significanceno p-value reported

Survival Analysis While there was an observed difference in survival between the two groups (mutated versus no mutated), this difference did not reach statistical significance.

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