C3a Mediates Endothelial Barrier Disruption in Brain-Derived, but Not Retinal, Human Endothelial Cells.

Although the short-term regulation of dnCI was observed 30 min after treatment initiation in HBMEC, the 500 nM C3a- and C5a-mediated reduction in paracellular resistance did not reach statistical significance when compared to the untreated control ( Figure 1 A and Supplement Figure S1A ).

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In HREC, 500 nM C5a showed a trend towards upregulation of C3AR1 gene expression 2 h after treatment initiation.

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