Intranasal Prime-Boost with Spike Vectors Generates Antibody and T-Cell Responses at the Site of SARS-CoV-2 Infection.

Although an intranasal vaccination with VSV-Spike-mIFNß induced a clear trend of increased numbers of anti-Spike, tetramer-positive T cells, this did not reach a significant level over IM-treated mice ( Figure 2 D).

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Intranasal vaccination with SC-Ad-Spike showed a trend towards differences between IM-vaccinated mice and IN-VSV-Spike-mIFNß vaccinated mice ( Figure 2 D).

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