[¹¹C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients.

The corresponding V T values showed a clear trend towards decreases in DRE patients relative to healthy subjects without reaching statistical significance (Fig. 4 ).

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The K 1 increases did not reach statistical significance in any investigated brain region and were in several epileptogenic TL sub-regions of DRE patients exceeded by k 2 increases (Fig. 4 ).

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