Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics.

A similar trend towards higher AUC 72h /DW in subjects who were UGT1A1 IM + PM compared to NMs was observed but it did not reach statistical significance either ( p uv = 0.121) ( Table 4 ).

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Volunteers with the ABCC2 rs2273697 A/A genotype showed a trend to higher C max /DW compared to the G/A genotype ( p uv = 0.087, p mv = 0.048, β = 0.267, R 2 = 0.067) ( Table 4 ).

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