Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia.

Plasma FGF23 levels were noted to be highest in group 4 and lowest in group 1, suggesting a potential effect of PHEX genotype on XLH disease severity, but this trend fell just short of statistical significance ( P = .13).

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However, since age is one of the factors affecting ectopic ossifications and the lower FGF23 group tended to be older than the higher FGF23 group, the subgroup analysis in patients older than 40 was also performed, in which these correlations did not reach statistical significance (Supplementary Table S4B) [ 27 ].

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Fibroblast growth factor 23 levels in women with NMD-insensitive mutations trended lower than in men with NMD-sensitive mutations but failed to reach statistical significance.

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