Disease Characteristics and Outcomes of 493 Young Myeloma Patients Treated With Modern Therapies: A Canadian Myeloma Research Group Database Study.

In the univariable analysis, patients with high‐risk cytogenetics showed a trend toward an increased likelihood of disease progression (HR 1.34, 95% CI: 1.00–1.81; p = 0.054) and a significantly increased risk of death (HR 2.08, 95% CI: 1.33–3.26; p = 0.001).

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In the multivariable model, there was a trend toward significance for disease progression (HR 1.41, 95% CI: 0.97–2.04; p = 0.068), and there was an increase in the risk of death (HR 2.20, 95% CI: 1.29–3.74; p = 0.004) with higher levels of LDH.

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Surprisingly, compared to stage I, ISS stages II and III did not reach statistical significance in univariable and multivariable analyses for disease progression and death.

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