Histone β-hydroxybutyrylation is critical in reversal of sarcopenia.

However, in the grip strength tests, while β‐HB treatment showed a trend towards increased strength, this difference did not reach statistical significance (Figure 2j ).

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Moreover, we investigated the β‐HB production potential across different age groups in human liver using the Genotype‐Tissue Expression (GTEx) dataset, and revealed a decreasing trend in the expression of these genes during the aging process in humans, with ACAT1 showing marginal significance (Figure S2 ).

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