Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice.

No difference in fecal IgA was seen before and after HFSD in WT male mice, whereas male Gpr183 –/– showed a strong trend ( P = .067) of decreasing IgA levels after HFSD ( Fig. 5B ).

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Female Gpr183 –/– mice showed a trend of overall lower levels with significantly lower levels of liver fibrosis markers Col1a1 and Mcp1 compared to WT females ( Fig. 4A ), a pattern opposite of that observed in VAT macrophage infiltration (see Fig. 3 ).

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