p63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysis.

In agreement with our metabolomic results, we found increased mRNA levels of fatty acid synthase ( FASN ) (2.49-fold, P < 0.0001), two isoforms of acetyl-CoA carboxylase ( ACACA , ACACB ) (1.37-fold, P = 0.032 and 1.69-fold, P = 0.0678, respectively) and citrate lyase ( ACLY ) (2.51 fold, P = 0.0335) which all increased significantly (or showed a trend towards a higher expression) in senescence (Fig. 3a, d and Table 1 ) but not in sip63 (Fig.

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S5b and Table 1 ), although they did not reach statistical significance.

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