Association Between the Enriched Environment Level and Serum Brain-Derived Neurotrophic Factor (BDNF) in Patients with Major Depressive Disorder.

Serum BDNF levels in CSs showed a tendency to be higher than in participants with MDD, although they did not reach statistical significance ( Table 1 ).

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Variations in BDNF Concentrations According to the Different Domains of Enriched Environment The means of BDNF levels in the different subgroups according to their total EE were compared with no significant differences ( p = 0.2401); again, the controls showed a trend toward higher serum BDNF concentrations than their respective comparisons with the participants with MDD ( Figure 3 ).

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