Altered Steroidome in Women with Multiple Sclerosis.

Regarding non-conjugated steroids, a highly significant trend towards lower values was observed (3/29/17, p = 0.008).

also in 23,678 other papers

However, the associations of these molar ratios with EDSS in patients showed a trend towards negative correlations (0/16/7, p = 0.009), and these associations with T25FWT showed a borderline tendency towards negative correlations as well (1/16/6, p = 0.061).

also in 11,799 other papers

Δ 5 and Δ 4 Steroids Aggregate results for Δ 5 and Δ 4 steroids showed a nonsignificant trend toward lower levels in patients than in controls.

also in 877 other papers

A significant trend towards higher ratios of conjugated steroids to their unconjugated counterparts was found in patients, which is of particular interest in terms of the balance between excitatory and inhibitory steroid modulators of ionotropic receptors.

also in 2,273 other papers

Since, with the exception of mid-cycle female sex hormones and the luteal menstrual phase, most steroids in women are synthesized either directly in the adrenal glands or from adrenal precursors [ 26 ] these results suggest an overall trend toward impaired adrenal activity in patients.

also in 1,214 other papers