Mitochondria-Targeted DNA Repair Glycosylase hOGG1 Protects Against HFD-Induced Liver Oxidative Mitochondrial DNA Damage and Insulin Resistance in OGG1-Deficient Mice.

Ogg1-KO mice fed LFD showed a trend toward lower lean body mass ( p = 0.1218, Supplementary Figure S1B ) and higher fat mass ( p = 0.1231, Supplementary Figure S1C ) compared to WT/LFD mice although neither difference was significant.

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The results of the clamp study showed a strong trend of increased insulin resistance with lower glucose infusion rates and whole-body glucose turnover and glycogen synthesis in HFD-fed Ogg1-KO mice compared to HFD-fed WT mice.

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