Emergent role of dynamic optimization in cardiac resynchronization therapy: Systematic review and network meta-analysis.

Indeed, in the SMART‐AV trial, CRT optimization showed a trend towards greater reverse remodelling compared with fixed device settings in patients with >30% atrial pacing. 6 Current algorithms mainly benefit patients with normal intrinsic AV conduction through the fusion of pacing and intrinsic electrical vectors.

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The primary outcome of all‐cause mortality or intervention due to HF decompensation was not significantly different between the two groups, although it showed a strong trend in favour of aCRT [hazard ratio (HR): 0.89, 95% CI 0.78–1.01].

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