Detection of Mismatch Repair Deficiency in Endometrial Cancer: Assessment of IHC, Fragment Length Analysis, and Amplicon Sequencing Based MSI Testing.

Analysis of the previously reported IHC and MSI statuses of these samples ( Table 1 ) confirmed there was a difference in assay concordance between Ohio and Manchester cohorts (18%) that was highly significant ( p = 1.2 × 10 −7 ).

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However, the differences did not reach statistical significance when comparing samples with MSH2 and MSH6 loss to samples without MSH6 loss ( p -values 0.30 and 0.07 and for Ohio and Manchester, respectively).

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This information was not recorded in the same way across the two cohorts (see methods), but a clear difference was apparent.

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