Multiple Myeloma Cells with Increased Proteasomal and ER Stress Are Hypersensitive to ATX-101, an Experimental Peptide Drug Targeting PCNA.

Cluster 3 ( Figure 3 A) showed an increasing trend in the pull-down from TK12-16, suggesting an increased activation of these proteins in all the sensitive cells.

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Cluster 2, on the other hand, showed a trend of decreasing pull-down from TK12-16, i.e., also reduced in the most sensitive TK16 cell line ( Figure 3 A).

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When all the proteins pulled down from ATX-101-treated cells were analysed in the same way as for untreated cells, we found only one cluster with a clear trend, i.e., an increase in the pull-down from TK12-16.

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