Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity.

There was no significant correlation between core body temperature and VMAT2 immunoreactivity in the vesicular/membrane fraction in the METH-treated rats ( Figure 4 d); however, the correlation between core body temperature and membrane/endosomal VMAT2 displayed a strong trend toward statistical significance ( p = 0.055, R 2 = 0.21, Pearson’s correlation test). 2.5.

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CDCrel-1 immunoreactivity showed a trend toward a statistically significant decrease in the vesicular/cytosolic fraction after binge METH administration in the WT rats (−33%, p = 0.079, n = 5, multiple unpaired t -tests with Holm–Sidak correction for multiple comparisons) ( Figure 7 b).

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